Question 1: Compare and contrast the mechanisms of action and main adverse effects of tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Also state the role or roles of each class in a stepwise approach to the management of depression pharmacologically; that is, explain which drug or drugs generally are chosen for first-line treatment and which generally are used only as a last resort and the reasons.
Question 2: Describe the best way to determine therapeutic lithium levels.
Question 3: Describe the most common adverse and toxic effects of amphetamines and their management, and discuss the issues of tolerance, physical dependence, and abuse.