Define symptoms in Nervous system of pernicious anaemia?
Parasthesia (numbness and tingling) occurs in fingers and toes. Occasionally, there are objective signs of involvement of the spinal cord (vitamin B12 neuropathy). In advanced cases, demyelination of the white fibres d the spinal cord occurs, &affecting first the dorsal column and later the lateral column. Historically, PA was considered to be the major cause of vitamin B12 deficiency, more recently, it has been suggested that a far more common problem is that of hypochlorhydria associated with atrophic gustritis, where there is a progressive reduction, with age, of the ability of the parietal cells to secrete hydrochloric acid.