Problem: A 47-year-old female presents with Stage IV breast cancer. Today, the PET scan reveals brain metastasis.
Q1. Define proliferation and differentiation and relate these changes to cancer.
Q2. Describe invasion, angiogenesis and metastasis.
Q3. There are three underlying causes of growth and maturity abnormalities: telomerase, pRB changes and 53 changes. Discuss these in relation to the patient.
Q4. Discuss tumor suppressor genes, oncogenes and DNA repair genes.