Define alzheimers disease


Answer the questions to this Nutrition Case Study. Please write your answers in green. Do not write a book report or an essay. Just answer these questions providing answers to all the questions thoroughly. I have listed below the top sources to use to answer these questions and the ADIME chart at the end. Use the Nelms and Krause sources first, if you do not find the answers in these two sources then go on and use other sources listed or whatever good references you find that answer the question. You have to have a knowledge in nutrition to answer these questions. My professor is more concerned with providing good answers then whether if this case study is well-written. Please contact me if there are any questions. Here are the list of references but feel free to use others:

Nelms, Sucher, Lacey, Long Roth: Nutrition Therapy and Pathophysiology. 3rd ed., Cengage Learning 2014

ISBN-13:978-1-305-11196-7

https://www.coursesmart.com/IR/1845467/9781305111967?__hdv=6.8

Nahikian-Nelms M, Long-Anderson S. Medical Nutrition Therapy: A Case Study Approach 4th ed. Belmont, CA: Wadsworth; 2013.

ISBN: 978-1-133-59315-7

Gylis BA, Wedding ME: Medical Terminology Systems (with Termplus 3.0): A Body Systems Approad (with medicallanguagelab.com), 7th Edition

ISBN: 978-0-8036-3575-3

eNCPT: https://ncpt.webauthor.com/

Brown JE, Isaacs J et al: Nutrition through the Life Cycle. 5th ed. Wadsworth 2014

ISBN-10: 1133600492, ISBN-13: 9781133600497

Nutrition Care Manual: https://www.nutritioncaremanual.org/member-pricing

Mahan LK, Escott-Stump S, Raymond, JL. Krause’s Food and the Nutrition Care Process. 13th ed. St. Louis, Missouri: Elsevier/Saunders; 2012. ISBN: 978-1-4377-2233-8

American Dietetic Association / American Diabetes Association. Choose Your Food: Exchange Lists for Meal Planning. 2008. (Either Diabetes or Weight Management booklet).

https://www.nhlbi.nih.gov/health/educational/lose_wt/eat/fd_exch.htm#1 also shows exchange lists, as do many other sites (.edu can be considered reliable for this purpose).

Pronsky ZN. Food Medication Interactions. 17th ed. Birchrunville. PA 2012. (optional; encouraged if on Dietetics Track)

ISBN: 0-9710896-4-7. Note: Choose your source – prices vary greatly!

Alternatively, consult epocrates, or rxlist.com for information on food-drug interactions.

Stedman’s Medical Dictionary for Health Professionals. 7th ed. Baltimore, MD: Williams and Wilkins; 2011 (optional; if not purchased use online medical dictionary i.e. https://www.medterms.com/script/main/hp.asp)

Wallach: Handbook of Interpretation of diagnostic tests. Current ed., Lippincott. Or any similar handbook on (human) diagnostic tests.

The following 4 books are resources for more in-depth studying:

Edelstein S and Sharlin J: Life Cycle Nutrition: An Evidence Based Approach. Jones and Bartlett 2009. ISBN 13: 978-0-7673-3810-5 (assigned chapters are included in the required textbook)

Samour P Q, King K: Pediatric Nutrition, 4th ed., Jones and Bartlett, 2012. ISBN-13: 978-0-7637-8450-8 (assigned chapters are included in the required textbook)

Chernoff R. et al.: Geriatric Nutrition: The Health Professional’s Handbook. Jones and Bartlett, 3rd ed., 2006. ISBN-13: 978-0-7637-3181-6 (assigned chapters are included in the required textbook)

McArdle WD, Katch FI, Katch VL: Sports and Exercise Nutrition, Wolters Kluwer, 4th ed., 2013. ISBN-13 978-1-4511-1806-3

Professional journals in nutrition and bio-medical disciplines (available in paper or online)

Rich website on the biology of aging and its relationship to diseases: American Federation for Aging Research https://www.afar.org/

Full-text journals – High-Wire press – https://highwire.stanford.edu/

Phytochemical and Ethnobotanical Database https://www.ars-grin.gov/duke/

FDA on Dietary Supplements: https://www.fda.gov/Food/DietarySupplements/default.htm

Additional References from American Nutritional Society – www.nutrition.org

PubMed – https://www.ncbi.nlm.nih.gov/pubmed/

The above are the best sources to use but feel free to use others after having used those.

Case study:

Note: This case study is based on cases in the Nelms books in combination with other cases to generate an original case study.

Pt Summary: FDE is an 85 year-old African American widower admitted through the emergency room from home for multiple abrasions and a non-healing wound on the right hip.

Patient has a Stage III full thickness non-pressure wound (laceration with purulent drainage and foul odor.

History:

Onset of disease: Pt was having difficulty taking care of his life-long home and immediate medical needs and has lived in a ground-floor apartment of his son’s home for the past 2 years. A nurse’s aide comes twice a day during daytime, and the son takes care of the patient when he is not working. The patient had been combative at times but is currently controlled, with current medications.

FDE had tripped on the steps to the main house 1 year ago and fractured his right hip. He underwent an open reduction/internal fixation surgery to repair the fracture. Blood loss during surgery was 350cm3. FDE was in inpatient rehabilitation for 10 days after discharge from the surgical service and then returned home. He ambulates with a walker.

Medical history: s/p MI x 2 at ages 45 and 62; HTN x 44 years, osteoporosis Dx 1 year ago

Surgical history: s/p 4 vessel CABG at age 62. R hip surgery 1 year ago

Medications at home: Furosemide 80mg daily, atenolol 25mg daily, Lisinopril 20mg daily, Zocor 40mg daily, haloperidol 0.5mg AM and PM, warfarin 5mg daily, donepezil 10mg PM; usually uses acetaminophen 500mg three times daily for pain.

Tobacco use: 1ppd x 45 years, quit 20 years ago.

Alcohol use: no

Family history: Father, uncles and brother all died before age 50 of MI, mother: dementia, not specified

Demographics:

Marital status: widower for 4 years

Years education: HS diploma

Language: English only

Occupation: electric company service technician

Ethnicity: African American

Religious affiliation: none

Admitting Hx/PE

CC: Patient reported to son that he fell and hit his hip on the corner of a table. He is admitted for evaluation of this non-healing wound.

General appearance:frail, thin elderly gentleman who is obviously confused and agitated. Well groomed but the clothes are loose fitting

Vital Signs: Temp: 100.3?, Pulse: 85, RR: 32, BP: 130/80,

height: 5’6”,

weight: 110lbs., usual body weight 140lbs (1 year ago, prior to hip surgery)

Heart: PMI sustained and displaced laterally, normal S1, S2+S3 at apex

HEENT: Head: WNL

Eyes: Pupils are small and react to light sluggishly, ocular fundus is pale, negative thyromegaly and adenopathy. +JVD – increased 4 cm above sternal angle at 45?

ears: clear

nose: clear

mouth: ill-fitting dentures, sore beneath bottom plate; cracks/fissures at corners of mouth (angular cheilitis), tongue is dry and pale without ulcers or plaques

throat: pharynx clear without postnasal drainage

genitalia: normal

neurologic: disoriented to time, place and person

extremities: no edema, Bruising. 2+ radial pulses, 1+ dorsalis pedis, and 1+ posterior tibial pulses bilaterally. DRT 2+ and symmetrical; strength 2/5 throughout DTR 2+ and symmetrical throughout

skin: pale, warm and dry, “ashy”-appearing patches of dryness and flaking to elbows and lower extremities. Multiple ecchymoses; open, draining purulent wound approximately 2cm x 2cm x 8cm located on right posterior thigh

chest/lungs: CTA and percussion with no rubs

abdomen: bowel sounds x4, nontender

Nursing Assessment (1 day ago)

Abdominal appearance (concave, flat, rounded, obese, distended) flat

Palpation of abdomen (soft, rigid, firm, masses, tense) Soft

Bowel sounds (P=present, AB=absent, hypo, hyper)

RUQ P

LUQ P

RLQ P

LLQ P

Stool color Light brown

Stool consistency Soft to liquid

Tubes/ostomies N/A

Genitourinary

Urinary continence catheter

Urine source catheter

Appearance (clear, cloudy, yellow, amber, fluorescent, hematuria, orange, blue, tea) Clear, yellow

Integumentary

Skin color Pale

Skin temperature (DI=diaphoretic, W=warm, dry, CL-cool, CLM=clammy, CD+=cold, M=moist, H=hot) CL

Skin turgor (good, fair, poor, TENT=tenting) fair

Skin condition (intact, EC-ecchymosis, A=abrasions, P=petechiae, R=rash, W=weeping, S-sloughing, D=dryness, EX=excoriated, T=tears, SE=subcutaneous emphysema, B=blisters, V=vesicles, N=necrosis) EC

Mucous membranes (intact, EC=ecchymosis, A=abrasions, P=petechiae, R=rash, W=weeping, S-sloughing, D=dryness, EX=excoriated, T=tears, SE=subcutaneous emphysema, B=blisters, V=vesicles, N=necrosis) Intact

Other components of Braden score: special bed, sensory pressure, moisture, activity, friction/shear (>18=no risk, 15-16=low risk, 13-14=moderate risk, ? 12=high risk) Activity, 13

Admissions orders:

Culture wound exudate

Scheduled for initial wound debridement with consult for wound management

Rx: Start 1.5g of ampicillin-sulbactam IV every six hours

(continued from home) Furosemide 80mg daily, atenolol 25mg daily, Lisinopril 20mg daily, Zocor 40mg daily, haloperidol 0.5mg AM and PM, warfarin 5mg daily, donepezil 10mg PM; acetaminophen 500mg three times daily for pain

Nutrition consult

Soft diet

Nutrition:

Usual dietary intake (24 hour recall, reported by son and nursing aide):

Breakfast: 1 jelly doughnut, 1 slice white toast with 2 tbsp. jelly, 1 cup coffee

Lunch: 2 butter cookies, 1 cup chicken and rice soup, 6 saltine crackers, 2 cups tea

Dinner: 1 slice white bread with 2 Tbsp jelly, 2 Tbsp peanut butter, 2 butter cookies.

Pt. had been refusing snacks and fruits and most vegetables since the hip surgery

Total calories: 1270, 25g/d protein, 42 g fat, 201 g carbohydrate; 153mg Ca, 6mg Fe

Reference range 1 day ago

Chemistry

Sodium (mEq/L) 136-145 136

Potassium (mEq/L) 3.5-5.5 3.5

Chloride (mEq/L) 95-105 96

Carbon dioxide (CO2, mEq/L) 23-30 27

BUN (mg/dL) 8-18 22

Creatinine serum (mg/dL) 0.6-1.2 1.3

Glucose (mg/dL) 70-110 82

Phosphate, inorganic (mg/dL) 2.3-4.7 2.5

Magnesium (mg/dL) 1.8-3 1.9

Calcium (mg/dL) 9-11 9

Bilirubin, direct (mg/dL) <0.3 0.1

Protein, total (g/dL) 6-8 5.5

Albumin (g/dL) 3.5-5 2.5

Prealbumin (mg/dL) 16-35 10

Ammonia (NH3, µmol/L) 9-33 24

Alkaline phosphatase (U/L) 30-120 80

ALT (U/L) 4-36 25

AST (U/L) 0-35 21

C-reactive protein (mg/dL) <1.0 5.1

CPK (U/L) 30-135 F

55-170 M 56

Cholesterol (mg/dL) 120-199 155

HDL-C (md/dL) >55 F, >45 M 33

LDL (mg/dL) <130 121

LDL/HDL ratio <3.22 F

<3.55 M 3.67

Triglycerides (mg/dL) 35-135 F

40-160 M 153

HbA1C (%) 3.9-5.2 4.6

Coagulation (Coag)

PT (sec) 12.4-14.4 13.1

PTT (sec) 24-34

Hematology

WBC (x 103/mm3) 4.8-11.8 16.0

RBC (x 106/mm3) 4.2-5.4 F

4.5-6.2 M 5.1

Hemoglobin (Hgb, g/dL) 12-15 F

14-17 M 13.5

Hematocrit (Hct, %) 37-47 F

40-54 M 37

Mean cell volume (µm3) 80-96 77

Mean cell Hgb (pg) 26-32 24

Mean cell Hgb content (g/dL) 31.5-36 30

Platelet count (x 103/mm3) 140-440 145

Transferrin (mg/dL) 250-380 F

215-365 M 165

Ferritin (mg/mL) 20-120 F

20-300 M 18

Hematology, Manual Diff

Lymphocyte (%) 15-45 10

Monocyte (%) 3-10 5

Eosinophil (%) 0-6 1

Segs (%) 0-60 50

Case study questions

1. Define dementia. Define Alzheimer’s disease (AD). How do they differ?

2. What are the current medical interventions available for the management of AD? What are the goals of these interventions?

3. FDE has a Stage III full thickness non-pressure wound. What does that mean?

4. Describe the normal stages of wound healing.

5. Name a minimum of three factors that support wound healing. Name a minimum of three factors tha may impair wound healing. Identify the most probable factors that may have contributed to FDE’s poor wound healing.

6. Describe the potential roles of zinc, vitamin A, vitamin C, copper, glutamine and arginine in wound healing.

Nutrition assessment

7. Assess this patient’s available anthropometric data. Calculate %UBW and BMI. Which of these is the most pertinent in identifying the patient’s nutrition risk? Why? (Note: assess means you also have to write if that is significant etc.)

8. Discuss the progressive weight loss FDE has experienced. Why is this of concern? What factors may have contributed to his weight loss?

9. Calculate energy and protein requirements for FDE and indicate a healthy distribution of macronutrients at that energy level (g protein, fat, CHO).

10. How would you determine the levels of micronutrients that FDE needs?

11. Identify all the medications that FDE is taking and complete the table below.

Medication Function Drug-nutrient interaction

Ampicillin-sulbactam

Furosemide

Atenolol

Lisinopril

Zocor

Haloperidol

Warfarin

Donepezil Acetylcholinesterase inhibitor N/D/V, muscle cramps, fatigue, anorexia;

acetaminophen

12. Which lab values can be used to further assess FDE’s nutritional status:

13. Which lab measures are related to the wound?

14. Select two nutrition problems and complete the PES statement for each.

15. For each of the PES statements that you have written, establish an ideal goal based on the signs and symptoms and an appropriate intervention, based on the etiology.

FDE’s oral intake is <50% of foods provided. He is observed to be coughing during feeding. A speech pathologist determines that he needs a level I dysphagia diet. On this diet, FDE’s intake declines further, to <25% of intake. After 3 days, another nutrition consult is ordered.

16. Is he a candidate for enteral feeding? Outline the pros and cons for recommending nutrition support for this patient. What are the ethical consideration?

The following feeding formulas are available:

Category DM standard Special protein Isotonic w/fiber High protein w/fiber

Product name Glucerna Select Boost Prostat Jevity 1.0 Osmolite 1.5

Usage oral/tube, B oral oral oral/tube TF

Indications can be sole source ok for TF

impaired glucose

tolerance

Allergies lactose-free lactose-free lact-free lactose-free

low osmolality has corn, milk gluten-free gluten-free

egg free has soy kosher kosher

low residue

Standard serving 8 fl.oz – 1 L 8 fl.oz 8 fl.oz./1 L 8 fl.oz./1 L

Nutrient values

kcal 240/ 8 fl.oz 60 /1fl oz. 250 8 fl.oz. 355/8 fl.oz.

kcal/cc 1.0 1.0 1.1 1.5

% H2O 84 84 76

kcal to meet 100% DV 1420 1400 1500

ml to meet 100% DVs 1420 1321 1000

protein g 10/ 8 fl.oz 15 /1 fl.oz. 10.4 /8 fl.oz. 14.9 /8 fl.oz.

protein g/L 50.0 44.3 62.7

Fat g 4/ 8 fl.oz 8.2 / 8 fl.oz. 11.6 /8 fl.oz.

fat g/l 54.4 34.7 49.1

CHO g 41/ 8 fl oz 36.5 /8 fl.oz. 48.2 /8 fl.oz.

CHO g/L 95.7 154.7 203.6

Sodium mg 940.0 548.5 930.0 1400.0

Potassium mg 1687.8 1800.0

Phosphorus mg 1000.0

mOsm/kg H2O 470.0 300.0 525.0

Fiber 11.8 0.0 14.4

Flavors Vanilla Vanilla

Chocolate Chocolate

Product name Glucerna Select Boost Prostat Jevity 1.0 Osmolite 1.5

17. Complete a tube feeding order form for this patient, to add to his level I dysphagia diet.

Formula:

Provides:

Kcal:

Protein:

CHO:

Fat:

Water:

Feeding method: continuous / intermittent / cyclic

Initiation and progression: (___cc/hr, adv. Every 8 hrs by ___ cc until goal rate achieved)

Goal rate: _____cc/hr, x ___hrs/d

Flushes: __x ___cc (____ cc)

Total water provided: ______ cc

18. Complete the ADIME sheet (before the tube feeding).

A – Assessment

S – Subjective

Chief Complaint:

UBW:

Weight change: gain / loss

Appetite:

Chewing / swallowing problem / sore mouth

Nausea / vomiting / diarrhea / constipation

Food intolerance / allergies:

Diet prior to admit: Nutritional supplement:

Vitamins / herbs:

Food preparation:

Factors affecting food intake:

Social / cultural / religious / financial

Other:

O – Objective

Current Diet Order:

Medical Diagnosis:

Past Medical History:

Nutrition Focused Physical Signs & Symptoms:

Age:

Gender: Male ?

Female ? Ht: Wt: Admit ?

Current ? DBW: BMI:

% UBW:

% wt ?: % DBW: Other:

Nutritionally Relevant Laboratory Data:

Drug Nutrient Interaction:

A – Assessment (A)

State no more than 2 priority Nutrition Diagnosis statements in PES Format. Use Nutrition Diagnosis Terminology sheet

ND Term (Problem) related to (Etiology) as evidenced by (Signs and Symptoms) :

1.

2.

Nutrition Intervention (I)

P – Plan

List Nutrition Interventions. Use Nutrition Intervention Terminology sheet. (The intervention(s) must address the problems (diagnoses).

Goal(s):

Plan for Monitoring and Evaluation (M E)

List indicators for monitoring and evaluation. Use Nutrition Assessment and Monitoring & Evaluation sheets. (Upon follow-up, the plan for monitoring would indicate if interventions are addressing the problems).

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Biology: Define alzheimers disease
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