Problem: A young woman presents with complaints of burning on urination, frequency, and urgency. Phenazopyridine (Pyridium) is prescribed. What specific directions should the nurse practitioner provide for this client regarding phenazopyridine? A young woman presents with complaints of burning on urination, frequency, and urgency. Phenazopyridine (Pyridium) is prescribed. What specific directions should the nurse practitioner provide for this client regarding phenazopyridine? May discolor contact lenses; if sclerae begin to turn yellow, return to the office. Always take on an empty stomach to increase absorption. Do not take any medication containing aspirin or salicylate. May interfere with effectiveness of mini-pill for birth control.