Problem:
Question 1: List the criteria that are used to determine whether a chemical serves as a neurotransmitter. What are the various experimental strategies you could use to show that ACh fulfills the criteria of a neurotransmitter at the neuromuscular junction?
Question 2: Compare and contrast the properties of (a) AMPA and NMDA receptors, and (b) GABA A and GABA B receptors.
Question 3: Glutamate activates a number of different metabotropic receptors. The consequence of activating one subtype is the inhibition of cAMP formation. A consequence of activating a second subtype is activation of protein kinase C. Propose mechanisms of these different effects.
Question 4: Ca2+ ions are considered to be second messengers. Why?
Include source of information for best answer.