Clinical Manifestations
i) Evidence of Systemic Infection
Fever, chills, rigor, night sweat, loss of weight, arthralgia, arthritis, backache, muscle pain.
ii) Evidence of Intra-vascular Lesions
- Splinter haemorrhages (black longitudinal streaks) that may occur in the nail beds.
- Petechiae common in conjunctivae, lips buccal mucosa, over ankles, feet and the antecubital and popliteal areas.
- Osler's nodes (painful, tender, red or purple, pea-sized lesions) seen on the fingertips or toes.
- Janeway's lesions-flat, painless small red spot on the palms and soles.
- Fundoscopic examination may reveal haemorrhagic retinal lesions (Roth's spots).
- Heart murmur is seen if aortic and mitral valves are affected. Patient may go into heart failure.