Question: Which is the most important question the nurse should ask a client with ulcerative colitis prior to administering sulfasalazine (Azulfidine)? Which is the most important question the nurse should ask a client with ulcerative colitis prior to administering sulfasalazine (Azulfidine)? "Are you experiencing any pain?" "Are you currently experiencing any diarrhea?" "Do you have any medication allergies?" "What other prescriptions have you take for ulcerative colitis?"