Assignment Problem: Early diagnosis and proper monitoring and treatments can help children with Hyper IgM avoid some life threatening infections. However, without a successful bone marrow transplant the life expectancy of those with Hyper IgM is only -30 years of age. At 14 years of age Daniel was able to receive a bone marrow transplant from his sister. The transplant was successful and Daniel is now in graduate school studying primary immunodeficiencies (primary immunodeficiencies are caused by inherited genetic mutations/variants).
Daniel is currently working with different strains of mice, each with a homozygous deletion of a key immune system associated gene. He needs to confirm the presence or absence of different cell stages in each of the mice.
You are told the deleted gene in each strain of mouse. Choose whether you expect to see each of the listed B-cell and T-cell stages, or antibodies.
Just fill in the blanks with either 1- Yes; would be present or 2- No; would not be present.
Artemis - antibodies _____ , IgG antibodies _____ , pro B-cells _____, immature B-cells _____ , mature B-cells _____ , DP Thymocytes _____ , SP Thymocytes _____ , Mature T-cells _____ , Vpre? - antibodies _____ , IgG antibodies _____, pro B-cells _____, immature B-cells _____ , mature B-cells _____ , DP Thymocytes, _____, SP Thymocytes _____ , Mature T-cells _____, Iga and Igß (both are knocked out/deleted) - antibodies _____ , IgG antibodies _____ , pro B-cells _____ , immature B-cells . _____ , mature B-cells ___, Dp Thymocytes * _____ , SP Thymocytes * _____ , Mature T-cells _____, TDT - antibodies _____ , IgG antibodies _____, pro B-cells _____, immature B-cells _____ , mature B-cells _____ ,DP Thymocytes - _____ , SP Thymocytes _____ , Mature T-cells.
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