Problem: Autosomal recessive disorder Mutation in the CFTR gene results in alteration in chloride and water transport across the apical surface of epithelial cells Manifestations: thick sputum, recurrent pulmonary infections, clubbing, dyspnea, tachypnea, moist basilar crackles and rhonchi, barrel chest Diagnosis: ABG, PFT, genetic testing, sweat testing Treatment: bronchodilators, chest physiotherapy, antibiotics for infections, potential heart and lung or lung transplant. Need Assignment Help?