Question - 1- As discussed, new mutations are part of DNA replication. The overall error rate of DNA biopolymerase in the replisome is 10-8 errors per base pair in humans. Repair enzymes fix 99% of these lesions. The human haploid genome is 3.2 * 109 bp.
a. What is the average number of mutations introduced when the genome is replicated?
- In males, there are approximately 400 cell divisions between zygote and production of a sperm cell.
b. How many mutations are to be expected in every sperm cell?
- In a female, there are about 30 cell divisions between zygote and production of egg cell:
c. How many mutations are expected in an egg cell?
d. How many mutations are expected in a new zygote?
e. Give a brief explanation what these mutations can result in from the evolutionary view, assuming they are a mutation that causes an amino acid change in a protein.