Antibiotic resistance is a wide spread public health issue. Explain why resistance develops so quickly, spreads so rapidly and widely, and is so hard to eradicate. Describe how the R plasmid is involved in the spread of multiple antibiotic resistance, and how the F factor plays a role. Next, describe three specific mechanismsof antibiotic resistance. If you were a research scientist at apharmaceutical company, which of the three mechanisms you just described would be the one you would select for development of new drugs to combat resistance, and why?