Question: What are the advantages of using specific immune globulin or intravenous immune globulin over vaccinations? Check All That Apply SIG will take effect immediately and offer protection right away. SIG will take effect immediately and offer protection right away. SIG takes time to develop but offers long lasting immunity. SIG takes time to develop but offers long lasting immunity. SIG is useful for immunocompromised patients who cannot be vaccinated. SIG is useful for immunocompromised patients who cannot be vaccinated. SIG contains denatured antigens so it is safer than vaccination.