Problem: The nurse is preparing to administer an atypical antidepressant bupropion (Wellbutrin) to a patient. The nurse knows which of the following are correct? Select all that apply. Exact mechanism by which depression is relieved is unclear, but may be related to blockade of dopamine and/or NE reuptake. Antidepressant effects begin in 4 to 6 weeks. Patients should discontinue MAOIs at least 2 weeks before starting bupropion. Also used to treat seasonal affective disorder and smoking cessation.