Sickle cell anaemia:
Sickle cell anaemia is the genetic syndrome caused by autosomal mutant allele Hbs. In homozygous situation (Hbs Hbs), it causes the making of abnormal haemoglobin termed as haemoglobin S. The usual haemolobin is designated as HbA (HbAHbA). Sickle cell persons with the genotype HbsHbs suffer from a fatal haemolytic anaemia. The patient expires due to damaged kidney, heart, spleen and brain as an outcome of clogged blood vessels or vascular obstruction. The person with heterozygous genotype HbA Hbs is state to be carriers and they survive.
Causes of Sickle cell anaemia:
Insufficient production of red cells:
Excessive loss of red cells:1) by external blood loss (i.e., hemorrhage)2) by shortened survival of red cells in the circulation3) Defective red cells (i.e., hereditary hemolytic anemia)
4) "Hostile environment"
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