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  Huntington’s chorea

Huntington’s chorea:

This is a deadly disease caused by an autosomal dominant gene in human beings. The onset of the disease is among 35 and 40 years of age. It is characterized by unrestrained jerking of the body due to involuntary twitching of voluntary muscles. It directs to progressive degeneration of the central nervous system accompanied by steady mental and physical deterioration. Huntington’s disease was primary completely dominant human genetic disease which comes into light. The affected gene is situated on chromosome 4. The other characteristics of this disease are deterioration of intellectual faculty, occasional hallucination, depression, and delusions and other psychological troubles. This disease is not curable.

Symptoms of the disease can differ among individuals and even amongst affected members of the same family, though generally progress predictably. The earliest symptoms are frequently subtle problems with mood or cognition. An usual lack of coordination and an unsteady gait frequently follows. As the disease advances, uncoordinated, jerky body movements become more obvious, all along with a decline in mental abilities and behavioral and psychiatric troubles. Physical abilities are generally impeded until coordinated movement becomes much difficult. Mental abilities usually decline into dementia. Complicationslike  heart disease, pneumonia,and physical damage from falls decrease life expectancy to around 20 years after symptoms start. There is no cure for Huntington’s Disease, and full-time care is needed in the later phases of the disease. Existing pharmaceutical and non-drug treatments can relieve most of its symptoms.

 

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