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  Different Biological databases

Different Biological databases:

Nucleic acid sequence databases:

European Molecular Biology Laboratory (i.e., EMBL); National Centre for Biotechnology Information (i.e., NCBI) and DNA data bank of Japan (i.e., DDBJ) are the three leader institutes considered as the authorities in the nucleotide sequence databases.

Protein sequence databases:

The protein sequence databases explains the high level annotations like the explanation of the protein functions; their domain structure (i.e., configuration), amino acid sequence, post-translational modifications, variants and so on. SWISS-PROT groups at SIB (i.e., Swiss Institute of Bioinformatics) and EBI (i.e., European Bioinformatics Institute) have built up the protein sequence databases.

Genome sequencing:

The genome of an organism can be divided into different sized molecules by a method termed as electrophoresis. Whenever DNA of an organism is subjected to electrophoresis they migrate towards the positive electrode since DNA is a negatively charged molecule. Smaller DNA fragments move quicker than longer ones. By comparing the distances which the DNA fragments migrate, their number of bases could be eminent. The series of bases in the DNA fragments can be recognized by chemical or biochemical techniques. Nowadays automated sequencing machines termed as sequenators are building up to read hundreds of bases in the DNA. The DNA sequence data are then stored in a computer available form.

 

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