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Introduction to Biophysical chemistry

Biophysical chemistry is a comparatively new field of chemistry that covers a wide spectrum of research activities that involves biological systems. The general characteristic of the research in this subject is to find out the explanation of the several phenomena in biological systems in terms of either the molecules that make up the supra-molecular structure or the system of these systems.

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To probe the structure of biological systems Biophysical chemists use several methods used in the field physical chemistry. These methods get include spectroscopic methods such as X-ray diffraction and nuclear magnetic resonance (NMR). For instance, the effort for which Nobel Prize was awarded in the year 2009 to the three chemists was based on x-ray diffraction studies of ribosomes. Some areas where biophysical chemists busy themselves are the functional structure and protein structure of cell membranes. Illustration for this is, enzyme action can be described in terms of the shape of a pocket in the protein molecule which matches the shape of the substrate molecule or its alteration because of binding of a metal ion. Same as the function and structure of the biomembranes can be understood from the study of model supramolecular structures as leptosomes or phospholipid vesicles of different sizes and compositions.

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