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  Pathogenesis of Brucellosis

Pathogenesis:

The incubation period might last around 10 to 30 days and the infection might persist without showing any symptoms. When there is no fluctuation in the temperature, diagnosis might be hard. All the species are pathogenic to man. The organism enters the body via skin abrasions, the mucus membrane of the alimentary and respiratory tracts. It reaches blood stream via the lymphatics. The infection might be there without generating any symptoms or it might cause classical undulant fever. The organism generates granulamatous lesions in the reticuloendothelial system, spleen, liver, and bone. Complications might include any portion of the body. The organisms might survive within the granulamata and cause relapses or hypersensitivity reaction.

Clinical manifestations:

Symptoms are related with continued illness and vague symptoms of malaise, insomnia, low grade fever, irritability and joint pain with swelling. After such chronic brucellosis acute attack might be seen after numerous years.

 

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