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  Organs and Cells of Immune System

Organs and Cells of Immune System:

Development of Cells in Thymus:

Thymus plays a significant role in T cell development.

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 Figure: Thymus

Thymus in mammals is a bilobed organ, situated in the thoracic cavity overlying the heart and main blood vessels. Each lobe is organized into lobules estranged from each other by a connective tissue termed as trabeculae in each lobule the lymphoid cells (i.e., thymocytes) are arranged into medulla and cortex.

The cortex has relatively immature thymocytes. In medulla more mature thymocytes are viewed. Immature prethymic cells from bone marrow come to cortex where they grown-up. Three kinds of epithelial cells are existed in the thymic lobules. They are:

1. Epithelial nurse cells that are in the outer cortex

2. The cortical epithelial cells that form a epithelial network and

3. The medullary epithelial cells that are systematized into clusters.

In adding up to these cells interdigitating dendritic cells (i.e., IDC) and macrophages both derived from bone marrow are also viewed in thymus. Such two cells are found in corticomedullary junction. Epithelial cells, IDC and macrophages hold main histocompatibility MHC molecule that are crucial for T cell development and choice.

 

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