Clinical findings:
Infection with F. hepatica or F. gigantica is termed as Fascioliasis. In mild infections Fascioliasis might be asymptomatic. Infection with large number of flukes can be too severe and might cause death of the host. In early phases hemorrhage and necrosis of the liver tissues take place due to the migration of young flukes. At this phase fever, eosinophilia, abdominal pain, and diarrhea take place. Once adults are established in the bile ducts, these symptoms might vanish but abdominal pain and attacks of fever and nausea might continue for years. In heavy infections fluke induced fibrosis of the bile duct might lead to the obstructive jaundice.Laboratory diagnosis:
Treatment prevention and controlode:
For infection with Fasciola species, bithionol and hexachloroparaxylene are efficient. Triclabendazole is found to be extremely efficient against adult and immature phases of F.hepatica. A significant preventive measure is to educate the public concerning the mode of transmission of the parasite and the dangers of eating un-cooked, contaminated vegetables. Prevention of fecal contamination of waters employed for plant growing where infected sheep and cattle or swine and humans are present is also necessary.
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