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  Botulism

Botulism:

Botulism is a harsh, fatal form of food poisoning with characteristic neurotoxic effects. The disease has been caused by a broad range of foods generally preserved food, home preserved vegetables, meat, canned products like fish, liver paste and even honey.

Foods accountable for botulism might not show signs of spoilage. The preformed toxin in the food is absorbed from intestinal tract. This is a protein and is not inactivated by the intestinal proteolytic enzymes. The toxin is made of two parts. A is the small part & B is the larger one. The larger part attaches to the mortor nerve end plates. The smaller part blocks the calcium mediated discharge of acetyl chorine.

Wound Botulism:

Rare conditions of wound infections with C. botulinum have been reported.

Infant Botulism:

Young children generally less than 6 months are affected by C. botulinum and the organisms colonize the intestine as resistance is poor. There are different grades of syndrome. They build up poor feeding, weakness and signs of paralysis. This is one of the reasons of rapid death syndrome. Organisms and toxin are found in the faeces and not in the blood. The reason might be the presence of spores in the honey that is employed for feeding. The spores germinate and create toxins in the infant gut.

 

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