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  Oxidative decarboxylation of pyruvic acid

Oxidative decarboxylation of pyruvic acid:

The two molecules of pyruvic acid created from a glucose molecule move into mitochondria and are decarboxylated, oxidized to two molecules of acetyl coenzyme A (acetyl Co~A). These 2 carbon compounds are created through dehydrogenation and decarboxylation.

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This reaction is catalyzed through pyruvic dehydrogenase and 2 molecules of NAD+ are reduced to NADH. Throughout this reaction 2 molecules of CO2 are released. Oxidative decarboxylation of pyruvic acid takes place just only under aerobic condition. Within anaerobic conditions, the pyruvic acid is reduced either to lactic acid or ethyl alcohol relies on the nature of the organism.

 

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