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  Decarboxylation

Decarboxylation:

This consider to the removal of CO2 (carbon dioxide) from the carboxyl group of amino acids. The elimination of CO2 requires the catalytic action of the pyridoxal phosphate coenzyme and enzymes decarboxylases. The enzymes work on amino acids resultant in the creation of the corresponding amines along with the liberation of CO2

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There are various amino acid decarboxylases make out in several tissues like liver, spleen, kidney, intestine, lung and brain. They translate the amino acids into the relevant amines and liberate CO2. For instance, histidine is transformed to histamine via the action of histidine decarboxylase.

The amino acid tryptophan is transformed to tryptamine, tyrosine to tyramine, etc. This types of amines are known biogenic amines that are physiologically significant.

 

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