--%>
Assignment Help - homework help

Sickle cell anemia

In sickle cell anemia, a genetic disease, there is replacement of one amino acid by other in one of the four polypeptide chains of hemoglobin. In this situation are all structural levels of the protein altered?

E

Expert

Verified

In sickle cell disease there is a modify in the primary protein structure of one of the polypeptide chains which form hemoglobin: the amino acid glutamic acid is replaced by the amino acid valine in the β chain. Spatial conformation of the molecule in adding up is as well affected and altered by this primary “mistake” and the modification as well makes a distinct (sickle) shape to the red blood cells.

Modified, sickled, red blood cells at times aggregate and hinder the peripheral circulation causing tissue hypoxia and the pain crisis usual of sickle cell anemia.

   Related Questions in Biology

  • Q : Elements which comprise the internal ear

    Name the elements which comprise the internal ear? Describe the functions of such structures?

    		•
  • Q : Adaptation to terrestrial life Explain,

    Explain, why is occurrence of eyelids in the amphibians as compared to their absence in fishes as an adaptation to the terrestrial life?

    		•
  • Q : What is Automated Voice Response or AVR

    Automated Voice Response (AVR): Commonly abbreviated as AVRS is another word for the more general definition (interactive voice response). It is a computer telephony phone application and hardware which accepts voice input and or touch-phone keypad ch

    		•
  • Q : Significance of glucose blood level

    State the significance of glucose blood level for the health of human?

    		•
  • Q : ELEMENTS OF DECISION MAKING ELEMENTS OF

    ELEMENTS OF DECISION MAKING There are following elements in decision making: 1 the decision maker.

    Q : Feature of a pharmaceutical

    Describe the most challenging feature of a pharmaceutical representative?

    		•
  • Q : What is Reorganization Reorganization :

    Reorganization:A) Reformation of a firm's operations, in order to focus on core actions and outsource peripheral ones, frequently needing reduction in workforce. B) Combination of two or more organizational u

    		•
  • Q : Cells of connective tissue Are the

    Are the cells of connective tissue faraway or near to the others? Answer: The relative big spacing among cells is a typical characteristic of the connective tissue.

    		•
  • Q : Why is buprenorphine less addictive

    Why is buprenorphine less addictive than other opioids (such as fentanyl) - is it understandable by its strength of binding to the general receptor?

    		•
  • Q : Discrimination-Barriers to Diversity-

    Barring an individual from membership of an organization or from a job because of his or her membership of a particular group. An example of unfair discrimination is the company that only interviews men for a position that requires a lot of travel.  

    		•