Preclinical data
Do you know how the dose for children is being estimated based on preclinical data?
Expert
There are numerous ways of estimating children's doses from preclinical (that is, adult) data - frequently depends on the therapeutic index of drug in question (that is, the wider the therapeutic window the lesser accurate the child's dose requires to be). At times straight weight-basis that is, 7kg child gets 1/10 dose of the 70kg adult.
More accurately it is a dose based on the body surface area (that is, child's surface area is bigger in proportion to its body weight as compare to adult). There are normograms to evaluate surface area from height and weight of child.
All of such might be wrong when clearance of drug in child is considerably dissimilar from adult example: distinct metabolism or various route of clearance.
Specify the structure by which neural impulse is transmitted from one cell to the other? Specify its parts?
Considering the toxicity and the need for dilution in the water compare the ureotelic and the uricotelic excretions? Write some of the examples of animals which have these respective types of excretion?
Define the term Generation Y and their characteristics in Generation groups of Employees ?
Name the type of digestive system in the molluscs? Answer: Molluscs existed extracellular digestion and a whole digestive system, with anus and mouth.
Regarding the volition of individual, how can reactions of nervous system can be classified?
Sources of Leader Power: Legitimate power: stems from position in the management hierarchy and the authority given to this position. Reward
Give a brief explanation of biotic factors.
How the cellular immune response does happen?
Are fruits always flesh part of “fruits”? Is edible part of the onion a fruit?
Channel Development: The condition whenever a company tries to raise its sales via a specific distribution channel or grouping of channels. A well-constructed and executed channel program will raise the size of your sales force and as
18,76,764
1943081 Asked
3,689
Active Tutors
1452271
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!