Preclinical data
Do you know how the dose for children is being estimated based on preclinical data?
Expert
There are numerous ways of estimating children's doses from preclinical (that is, adult) data - frequently depends on the therapeutic index of drug in question (that is, the wider the therapeutic window the lesser accurate the child's dose requires to be). At times straight weight-basis that is, 7kg child gets 1/10 dose of the 70kg adult.
More accurately it is a dose based on the body surface area (that is, child's surface area is bigger in proportion to its body weight as compare to adult). There are normograms to evaluate surface area from height and weight of child.
All of such might be wrong when clearance of drug in child is considerably dissimilar from adult example: distinct metabolism or various route of clearance.
Mistakes might take place throughout every copying procedure. The same is true for the DNA replication. Are there amendment systems in cells which try to fix those mistakes? Under which circumstances are the mistakes taken only by individual owner of the cell in which
Why can it be stated that each glucose molecule executes the Krebs cycle twice?
Write down the function of myelin sheath? Do all axons present the myelin sheath?
Name the beings which form the kingdom Plantae? Are algae, parts of this kingdom?
Explain the evolutionary significance of the fruits for angiosperms?
Which part of human visual system where the receptors that sense light, that is, the photoreceptor cells, are situated? How do those cells effort?
Briefly illustrate the term Equity Theory?
Describe the major ecological roles of bacteria?
Margin Improvement: Margins in the industry kept beneath pressure, even previous to the economic downturn for the industry as entire, returns on capital have continued beneath the cost of capital. Previous to the falls in the second half of 2008, the
Explain what is function of the venous and arterial blood?
18,76,764
1932684 Asked
3,689
Active Tutors
1444225
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!