Preclinical data
Do you know how the dose for children is being estimated based on preclinical data?
Expert
There are numerous ways of estimating children's doses from preclinical (that is, adult) data - frequently depends on the therapeutic index of drug in question (that is, the wider the therapeutic window the lesser accurate the child's dose requires to be). At times straight weight-basis that is, 7kg child gets 1/10 dose of the 70kg adult.
More accurately it is a dose based on the body surface area (that is, child's surface area is bigger in proportion to its body weight as compare to adult). There are normograms to evaluate surface area from height and weight of child.
All of such might be wrong when clearance of drug in child is considerably dissimilar from adult example: distinct metabolism or various route of clearance.
How does poliomyelitis influence neural transmission in spinal cord?
Do protozoans contain a cellular nucleus?
This type of communication refers to communication between various departments or units representing the same level, or people within the same or different departments, without having a superior-subordinate relationship. It flow between persons at the same hierarchical level. The main object of t
This is the last step of Taxonomy. The scientific method used in research involves observation, deduction and verification. The research methodology, i.e. the formation of objectives, developing hypothesis, collection of date, analysis and interpretation of data and i
Explain the defend mechanism of the body from the microorganisms and other harmful substances which may enter the airway during breathing process?
State the organ in which most of the clotting factors are produced? Also specify the role of vitamin K within the blood coagulation?
What do you mean by type IV hypersensitivity?
Which disease is caused by the deficiency of the dietary iodine?
What process causes bread to rise and what is the product
Employee Surveys: Technique of obtaining candid estimation of employees by giving them a chance to anonymously respond queries rose in the questionnaire. Conducting annual, bi-annual, and yet monthly human resource
18,76,764
1936322 Asked
3,689
Active Tutors
1417290
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!