Preclinical data
Do you know how the dose for children is being estimated based on preclinical data?
Expert
There are numerous ways of estimating children's doses from preclinical (that is, adult) data - frequently depends on the therapeutic index of drug in question (that is, the wider the therapeutic window the lesser accurate the child's dose requires to be). At times straight weight-basis that is, 7kg child gets 1/10 dose of the 70kg adult.
More accurately it is a dose based on the body surface area (that is, child's surface area is bigger in proportion to its body weight as compare to adult). There are normograms to evaluate surface area from height and weight of child.
All of such might be wrong when clearance of drug in child is considerably dissimilar from adult example: distinct metabolism or various route of clearance.
How reproduction is completed in beings of class Reptilia?
Comparing the toxicity and requirement for dilution in water how dissimilar are the ureotelic and the uricotelic excretions? Give some illustrations of animals which present such respective kinds of excretion?
Write down three main groups in which mammals are divided?
Write down the main events of final mitotic period.
Determine the chambers does fish heart contain? Answer: The fish heart is a tube made up of two consecutive chambers: one atrium and one ventricle.
How the intensity of simple diffusion is differ in relation to the concentration gradient of the moved substance?
What are the major components of the cytoskeleton?
Briefly explain Immunoglobulin (Ig) A.
Briefly describe the term chicken embryo technique?
Explain the term function group in brief? Answer: The atom or group of atoms that find out the characteristic properties of the Substance is termed as functional gro
18,76,764
1945946 Asked
3,689
Active Tutors
1453044
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!