Preclinical data
Do you know how the dose for children is being estimated based on preclinical data?
Expert
There are numerous ways of estimating children's doses from preclinical (that is, adult) data - frequently depends on the therapeutic index of drug in question (that is, the wider the therapeutic window the lesser accurate the child's dose requires to be). At times straight weight-basis that is, 7kg child gets 1/10 dose of the 70kg adult.
More accurately it is a dose based on the body surface area (that is, child's surface area is bigger in proportion to its body weight as compare to adult). There are normograms to evaluate surface area from height and weight of child.
All of such might be wrong when clearance of drug in child is considerably dissimilar from adult example: distinct metabolism or various route of clearance.
Give a brief explanation of cross-reaction.
What are Bronchi? Briefly illustrate it.
Name the substance generated in the liver which acts in the small intestine throughout digestion? How does that substance perform in the digestive process?
Define the term primary mediators in brief?
What is latent or inductive period?
How can you find out if a molecule is non-polar or polar?
Explain the androecium and the gynoecium? Specify the other structures of the flowers?
How dissimilar is the fish epidermis from amphibian epidermis?
Describe the term myoglobin? Write the function of such molecule in the muscle tissue?
Do phylogenetically proximal species include cells with proximal chromosome counts?
18,76,764
1935901 Asked
3,689
Active Tutors
1418051
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!