Models elucidating the formation of enzyme-substrate complex

Question

What are the major theoretical models which try to elucidate the formation of enzyme-substrate complex?

Answer 1

There are two major models which elucidate the formation of an enzyme-substrate complex: the lock and key model and the persuaded fit model. In the lock and key model the enzyme has an area with particular spatial conformation for the binding of substrate. In the induced fit model the binding of the substrate persuades modifications in the spatial configuration of the enzyme for the substrate to fit into it.