Mechanisms to decrease concentrations in synaptic cleft

Question

Since neurotransmitters are not consumed in synaptic process, what are the mechanisms to decrease their concentrations in synaptic cleft after they have been employed?

Answer 1

Since the binding of the neurotransmitters to postsynaptic receptors is reversible, after these neurochemicals carry out their role they should be eliminated from the synaptic cleft.

Neurotransmitters can then bind to particular proteins which carry them back to axon they came from in a procedure which is named as neurotransmitter re-uptake. They can also be destroyed by the particular enzymes, such as acetylcholinesterase, an enzyme which destroys acetylcholine. Or they can simply diffuse out of synaptic cleft.