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Factors which can lead to the protein denaturation

What are various factors which can lead to the protein denaturation?

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Protein denaturation can be lead by temperature variation, pH modification, modifications in the concentration of surrounding solutes and by certain other processes. Most of the proteins denature subsequent to some elevation of temperature or whenever in very acid or basic solutions. This is one of the main causes that it is essential for the organisms to keep stable pH and temperature.

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