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Factors which can lead to the protein denaturation

Write down some factors which can lead to the protein denaturation?

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Protein denaturation can be caused through temperature variation, pH change, and changes in concentration of surrounding solutes and by the other procedures. Most proteins denature subsequent to certain rise of temperature or when in very acid or extremely basic solutions. This is one of main reasons that it is essential for organisms to stay stable temperature and pH.

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