Diseases caused of abnormal GH secretion by hypophysis

Question

Explain the diseases caused because of abnormal GH secretion by the hypophysis?

Answer 1

In babyhood, underprovided GH secretion may lead to deferred growth and in severe cases to nanism (dwarfism). Extreme production of GH in children may cause exaggerated osseous growth and gigantism. In adults GH excess (e.g. in hypophiseal cancer or in people that wrongly ingest GH as a nutritional supplement) may lead to acromegaly, disproportional  and excessive growth of the bone extremities, the maxillaries, like the skull, the hands and the feet.