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Denatured enzyme-lock and key model

What takes place to the denatured enzyme regarding its functionality? How can that consequence be explained with the aid of lock and key model?

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According to lock and key model, enzyme functionality depends completely upon the integrity of activation center, a molecular area with the specific spatial characteristics. Subsequent to the denaturation the spatial conformation of protein is modified, activation center is destroyed and enzyme loses its catalytic action.

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