Homology Modelling is a process in which models are generated. The generated models may be conceptual or graphical or/and mathematical.So, we have different methods, tools and techniques for all kinds of modeling.Modelling methods are broadly classified in to two types and they are structural and functional. Structural modeling is based upon the structure of the molecule where as functional modeling is done based on the function. There are several methods in which structural modeling can be done. Homology modeling is one of them. It can also be called as comparative modeling, since it depends on the comparison of the given query sequence to the others until similar sequence is found. It can be done using different tools and techniques. The major research areas include sequence analysis, genome annotation, structural analysis and many more. This is applied in pharmacology and many more departments.