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Comparative Genomics

What are Comparative Genomics and what is the approach to Comparative Genomics?

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A) Comparative mapping has been an extremely useful tool for cross-species leverage of information

B) Comparative genomics can be even more powerful

C) It is a time consuming process

D) Databases have the potential to automate much of the work

E) Comparing data from databases is complicated by mismatches in

  • DBMS
  • Database schemas
  • Of course, projects such as Ensembl Genomes may solve such problems

Approaches to Comparative Genomics:

i) Warehousing:

  • Genomic data for many species  stored as one large ‘data warehouse’

ii) Middleware:

  • Applications
  • Templates (e.g. Biomart)
  • Ontologies (the Semantic Web)

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