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Cause of syndrome cretinism

Specify the physiological cause of syndrome which is known as cretinism?

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Cretinism is caused by the chronic deficiency of thyroid hormones (T4 and T3) during the childhood. The chronic hypothyroidism during the childhood can cause retardation and low stature because of the low basal metabolic rate in the period of life whenever the growth and development of mind faculties takes place.

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