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Biological functions in which the chlorine ions contribute

What are the major biological functions in which the chlorine ions contribute?

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Similar to sodium cations, chlorine anions actively contribute in the regulation of osmolarity of cells and tissues by crossing the cellular membrane and evading entrance of water into cell or extreme loss of water from the cell.

Chlorine anions contain a significant role for the acid-base balance of the organism as they participate, all along with bicarbonate anions, in the pH buffer system of body. The other function of chlorine is in the digestive physiology: within the gastric lumen, hydrochloric acid secreted by stomach cells ionizes itself into chlorine and hydrogen ions lowering the pH of the gastric juice and then allowing the enzymatic digestion to occur.

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